Background Abnormal lung volumes that reflect air trapping are common in COPD. However, their significance in smokers with preserved spirometry (normal FEV1 to FVC ratio) is unclear. Methods Using the ...

Recommendations Long-term macrolide treatment could be offered to reduce exacerbations in those with high exacerbation rates (ie, 3 or more per year). (Strong) The dosing regimens with the greatest ...

Background Antimicrobial resistance (AMR) is a growing global health crisis and is particularly relevant to people living ...

Asthma exacerbations are common. They account for a significant morbidity and contribute a disproportionate amount to the cost of asthma management. The optimal strategies for the prevention of asthma ...

Background: In some patients chronic asthma results in irreversible airflow obstruction. High resolution computed tomography (HRCT) has been advocated for assessing the structural changes in the ...

Background There is a lack of international consensus on the optimal programme design to maximise benefits from pulmonary rehabilitation (PR). Aim To investigate the effect of 1) exercise modality and ...

Background: Considerable research has been conducted into the nature of airway inflammation in chronic obstructive pulmonary disease (COPD) but the relationship between proximal airways inflammation ...

To determine whether asthma alone can cause irreversible airflow obstruction 42 men and 47 women with chronic asthma (mean duration 22 (SD 13) years) without evidence of other disease likely to cause ...

Background Up to 50% of patients suffering acute pulmonary embolism (PE) demonstrate impaired pulmonary vascular recovery at follow up despite optimal anticoagulation, impacting negatively on ...

Introduction Paediatric sleep diagnostics uses complex multi-channel tests in specialised centres, limiting access, delaying diagnosis and management. Children with neurodevelopmental disorders, at ...

Results 256 day case MTs were analysed. Mean age was 72 years (34–86), 93 patients were male. 64 patients (25%) developed post procedure SE, and 4 of those had concurrent air leaks (due to lung ...

Despite the debilitating and lethal nature of pulmonary hypertension (PH) secondary to interstitial lung disease (group 3 PH),1 research into the treatment of this unique category of vasculopathy ...