Real Madrid centre-back Antonio Rudiger is a major injury doubt for the titleholders’ Champions League clash with Manchester City.

Real Madrid will play Manchester City in the Champions League knockout playoffs round in a standout clash of the past two title winners after the draw was made Friday.

Friday's draw on CBS Sports Golazo Network detailed the start to the path to the Champions League final at Munich's Allianz Arena on May 31, resolving the next round of matchuops though team's ultimate paths remain unsettled. Teams ranked ninth through 16th at the end of the league phase were seeded and drawn against one of the unseeded teams.